Deoxythymidine 5 -phosphate

Deoxythymidine 5 -phosphate Th3fmine + deoxyribose + phosphate Nucleoside is 2 -deox3dh3miidine, composed of thymine and deoxyribose... 

The effect of solvation on the IPs of nucleotides has been investigated by Le-Breton and coworkers using a combination of photoelectron spectroscopy and computational methods. They conclude that the first and second ionization potentials of the nucleotides deoxycytidine 5 -phosphate (CMP) and deoxythymidine 5 -phosphate (TMP) arise from ionization of the negatively charged phosphate group and nucleobase, respectively, both in the gas phase and in solution. The difference in the calculated first and second ionization potentials is smaller for the hydrated versus gas phase nucleosides as a consequence of the larger solvation energy for the zwit-terion formed upon ionization of the nucleobase versus the neutral radical formed upon ionization of the phosphate. The calculated adiabatic ionization potentials for the hydrated nucleobases CMP and TMP are 5.8 and 6.0 eV, respectively, considerably lower than the gas phase nucleobase ionization potentials (Table 1). 

Deoxythymidine 3 -p-aminophenylphos-phate 5 -phosphate, 358, 360 Deoxythymidine 3, 5 -diphosphate, 358 Deoxythymidine 3 -p-nitrophenylphos-phate 5 -phosphate, 358 Deoxythymidine 3 -phosphate p-nitro-phenyl ester, 358, 360 Deoxythymidine 5 -phosphate p-nitro-phenyl ester, 358... 

Hybridization of a model ohgonucleotide was transduced electrochanicaUy using bioelectrocatalytic activity of horseradish peroxidase [32]. The primary oligonucleotide, poly(deoxythymidine)-5 -phosphate, (3), was cova-... 

The simultaneous replacement of uridine by deoxythymidine and galactose by a number of deoxy sugars to give non-natural donor substrates has also been reported [50], Partially protected a-sugar-1-phosphates were coupled to morpholidate-activated deoxythymidine-5-phosphate and subsequently deprotected in the presence of lithium hydroxide to give the corresponding dTDP sugars (see Table 1). 

Separation of 2, 3 -didehydro-3 -deoxythymidine 5 -(methoxyalaninyl phosphate) triethylammonium salt... 

Schwendener RA, et al. New lipophilic acyl/alkyl dinucleoside phosphates as derivatives of 3 -azido-3 -deoxythymidine Inhibition of HIV-1 replication in vitro and antiviral activity against Rauscher leukemia virus infected mice with delayed treatment regimens. Antivir Res 1994 24 79. 

The deoxyribonucleotides, except for deoxythymidine nucleotide, are formed from the ribonucleotides by the action of an enzyme complex, which comprises two enzymes, ribonucleoside diphosphate reductase and thioredoxin reductase (Figure 20.11). The removal of a hydroxyl group in the ribose part of the molecule is a reduction reaction, which requires NADPH. This is generated in the pentose phosphate pathway. (Note, this pathway is important in proliferating cells not only for generation... 

DEOXYRIBONUCLEASES 2 -Deoxyribonucleoside diphosphate, RIBONUCLEOTIDE REDUCTASE 2-DEOXYRIBOSE-5-PHOSPHATE ALDOLASE DEOXYTHYMIDINE KINASE DEP,... 

ADENYLOSUCCINATE SYNTHETASE DEOXYTHYMIDINE KINASE FUCOSE-1-PHOSPHATE GUANYLYL-TRANSFERASE... 

Adenosine 3, 5 -cyclic phosphate166 8-Bromoguanosine dihydrate167 D-Ribofuranosyl-6-thiopurine168 Inosine 5 -(sodium phosphate) octahydrate169 5-Bromo-5-deoxythymidine (form B)170... 

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