Deoxytedanolide antitumor activity

Peloruside A (31), which is a 16-membered, highly oxidized macrolide from the sponge Mycale hentscheli, induces tubulin polymerization (2). 13-Deoxytedanolide (32) isolated from Japanese sponges of the genus Mycale shows promising antitumor activity. It inhibits protein synthesis by binding to a 70 S large subunit of eukaryotic ribosome (17). 

Nishimura, S., Matsunaga, S., Yoshida, M., Nakao, Y, Hirota, H., and Fusetani, N. (2005b) Structure-activity relationship on 13-deoxytedanolide, a highly antitumor macrolide from the marine sponge Mycale adhaerens. Bioorg. Med. Chem., 13, 455-462,... 

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