2-deoxystreptamine 4.6-disubstituted

Derivatives Containing a 4,5-Disubstituted-2-deoxystreptamine Moiety. The first of this subclass to be isolated were the neomycins (B (9) and C), followed by paromomycin I [7542-37-2] 023114 X 024, and paromomycin 11 [51795-47-2] C23II43X3O24. The paromomycins are... 

Derivatives Containing a Modified 4,6-Disubstituted-2-deoxystreptamine Moiety. Mutasynthesis is the term used to refer to the process of employing mutated intermediate-requiring organisms to prepare derivatives that would be difficult to obtain by synthetic or semisynthetic means (117,185—188). Whereas this approach has been used to obtain amiaoglycoside analogues, the primary contribution has been as a means to vary the 2-deoxystreptamiae portion of the molecule. The most significant compound found by this approach is 5-episisomicin, which is produced by a... 

Strepto- mycin 4-5 disubstituted 2-deoxystreptamine Neomycin Paromomycin 4-6 disubstituted 2-deoxy-streptamine Monosubstituted 2-deoxy- streptamine (Hygrornycin)... 

There are several instances, however, in which the correlation between antibiotic sensitivity and possession of the prerequisite elements for antibiotic action is less straightforward. This is exemplified by thiostrepton, monosubstituted and disubstituted 2-deoxystreptamines and a-sarcin. 

Wong and coworkers in a recent investigation [163] studied the A-site-binding aminoglycosides, including the 4,5-disubstituted 2-deoxystreptamine derivatives (neomycin B, paromomycin, and ribostamycin) and the 4,6-disubstituted 2-deoxystrep-... 

C. 4,5-Disubstituted 2-Deoxystreptamine-Containing Aminoglycosides Neomycins, Paromomycins, Lividomycins, and Related Compounds... 

The 4,6-disubstituted deoxystreptamine aminoglycosides can be divided into kanamycins (Table 6) and gentamidns (Table 8), depending on the structure of the sugar moiety linked to the 6-po ition of the deoxystreptamine ring. 

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