Deoxypentosenucleic acids

The Separation of Deoxypentosenucleic Acids and Pentosenucleic Acids, S. K. Dutta, A. S. Jones, and M. Stacey, Biochim. Biophys. Acta, 10 (1953) 613-622. 

The Nucleotide Sequence in Deoxypentosenucleic Acids. Part II. The Alkaline Degradation of Calf-thymus aldehydo Apurinic Acid Di(carboxymethyl) Dithioacetal, A. S. Jones, D. S. Letham, and M. Stacey, J. Chem. Soc., (1956) 2579-2583. 

Preparation. The preparation of 2-deoxy-D-erythro-pentose by hydrolysis of the natural deoxypentosenucleic acids is tedious and the yields are low. The nucleic acids first are hydrolyzed enzymatically to deoxyribonucleo-sides (V-deoxyribofuranosyl purines and pyrimidines). Further mild acidic hydrolysis then liberates the sugar from the purine bases 57). The sugar-pyrimidine linkage, however, is more stable and its hydrolysis by stronger acid is accompanied by destruction of the deoxypentose to levulinic acid. Direct mercaptanolysis of deoxyribosenucleic acids has been employed to obtain the dibenzyl mercaptal of the deoxysugar 58). 

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