Dendritic supramolecule

Scheme 3. The synthetic route of the complete antibody dendrimers. An ideal structme of the dendritic supramolecule is shown as G1...

Scheme 5. Preparation of the dendritic supramolecules with protein A as a core and IgGs as branches...

The size of dendritic supramolecules and hybrid nanoparticles (typically 20-200 nm in diameter) affects their biodistribution in vivo. As their hydrodynamic diameters are larger than threshold of kidney ( 5.5 nm), their elimination rate from the body is typically slower and circulation time in the body is longer than dendrimers.[80] Another clearance mechanism via RES following intravenous administration is inversely dependent on their size, i.e., more efficient macrophage uptake of 90 nm nanoparticles than that of 15 nm nanoparticles.[81]... 

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