Dendritic polyglycerol

Transformations on this support included the synthesis of aminoketones from supported chloroketones as weU as biarylaldehydes after Suzuki cross-couphng reactions of supported bromo-benzaldehydes [21]. This dendritic polyglycerol was... 

Recently, Hebei and Haag reported on the immobilization of aryl boronic acids (62) on a dendritic polyglycerol support (15) (Fig. 7.8, M =8000 g mol ) (Scheme 7.10) [57]. This commercially available support was directly used and no additional... 

Haag et al. [43] have recently reported on the supramolecular immobilization of a perfluoro-tagged Pd catalyst on a dendritic polyglycerol ester with a perfluorinated shell and they have investigated its activity in Suzuki coup-... 

Fig. 13 a Synthesis of dendritic polyglycerol perfluorolkyl ester 18 from hyperbranched polyglycerol 17... 

Siegers C, Biesalski M, Haag R (2004) Self-assembled monolayers of dendritic polyglycerol derivatives on gold that resist the adsorption of proteins. Chem Eur J 10(11) 2831-2838... 

FIGURE 5.24 Sialic acid conjugated dendritic polyglycerol nanoparticles with diameters in the range of 60 nm efficiently block viral infections by polyvalent inhibition of the hemagglutinin in contrast to their smaller multivalent analog. Source Quadir and Haag [54]. Reproduced with permission from Elsevier. 

Calderon Marcelo, Quadir Mohiuddin Abdul, Sharma Sunil Kumar, and Rainer Haag. Dendritic polyglycerols for biomedical applications. Adv. Mater. 22 no. 2 (2010) ... 

Chiral manganese salen catalysts have been widely used for the asymmetric oxidation of unactivated olefins. The dendritic polyglycerol-supported Mn-salen catalyst (44) was developed for the asymmetric epoxidation of the chromene derivative in a continuous membrane fiow reactor. This fiow system involves the continuous removal of the product (and unreacted substrate) from the high-molecular-weight dendritic catalyst (44) by filtration through a nanomembrane (Scheme 7.33). Under optimal conditions, 70% conversion with up to 92% ee was achieved [133]. In this system, however, the dendritic catalyst (44) worked as a homogeneous catalyst rather than a heterogeneous one. 

Similar approaches have also been used in the field of dendritic polymers. Calderon et al. (2009) prepared polymer-drug conjugates from dendritic polyglycerol and maleimide-bearing prodrugs (Tyagarajan et al., 2003 ... 

Calderon, M., Graeser, R., Kratz, F. and Haag, R. (2009) Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol. Bioorg Med Chem Lett, 19,3725-3728. 

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