Dendritic construction

In a different approach, Hedrick et al. have studied multifunctional dendritic initiators for the synthesis of multiarm star-shaped copolymers [102]. Several dendritic initiators with hydroxyl functionality ranging from 2 to 48 have been prepared according to the method developed by Hult et al. [120]. The bulk polymerization of sCL initiated by these multifunctional macroinitiators and acti- 

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Repetitive silicon-based transformations were then employed for dendritic construction. Palladium-catalyzed silane hydroxylation of the core 71 afforded triol 73, which was then treated with three equivalents of monochloropolysiloxane 72 to generate the hexa-hydrido, first generation dendrimer 74. Further application of the Pd-mediated hydroxylation, followed by attachment of monochloro-monomer 72, led to the second (75) and third (76) generation polysiloxane cascades. 

In 1985, application of this simple dendritic construction to a polymer core, specifically chloromethyl functionalized polystyrene was reported. 139 Another example of the identical procedure was reported 140 except utilizing another polymeric core backbone, derived from a functionalized vinyl ether monomer. These are very early examples of dendritic comb macromolecules. 

Figure 5.7. A dendritic construction set was created based on Moore et aJ. s[941 phenylacetylene chemistry. (Aryl connectors consist of — = — bonds.)...

Step 1—Dendritic construction. This step consists in the identification of the core conditions leading to hazards in any given system. This analysis can be performed by means of a Preliminary Hazard Analysis. 

Coherently with the steps proposed by CCSM, for the creation of the model five steps are necessary, which consists in (1) Dendritic construction, (2) Random Sampling, (3) Control chart design (4) Test for out of control conditions, and (5) Action. 

Step I— The dendritic construction consists in the identification of the core conditions leading to hazards in the system. A preliminary hazard analysis has been performed in the monitored enterprise, and a checklist of behaviours leading to hazards has been identified. The dendritics leading to hazards have been classified in different groups. These dendritics are reported in Table 1. Many of the identified dendritics are workers behaviours however, some dendritics more related to contextual aspects, such as obstacles not clearly indicated, have been included. 

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