Dendrimers polynitrile

With this method new dendrimers were prepared in the following years by Denkewalter et al. [22], Tomalia et al. [23], Newkome et al. [24], and ourselves [25]. Following a reaction pathway similar to the one used in 1978, Meijer et al. successfully synthesized a polynitrile dendrimer 14 up to the fifth generation on a large scale [26] (Fig. 8). 

Womer C, Miilhaupt R (1993) Polynitrile-functional and polyamine-functional poly(trimethy-lene imine) dendrimers. Angew Chem Int Ed Engl 32 1306-1308... 

Dendrimers can be reacted with a variety of compounds to further functionalize them to give them unique characteristics. For example, amine-terminated dendrimer can be reacted with imsaturated nitriles to give a polynitrile dendrimer. In another case the polyamine dendrimer can be reacted with jS-unsat-urated amides to give amide-terminated dendrimer. A whole host of possibilities can be visualized based on the reactivity of the amino group [43]. 

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