Dendrimer divergent growth

Scheme 22. a) The divergent growth approach for the preparation of dendritic polyesters. b) The divergent approach for the preparation of dendrimer having 16-hydroxy groups... 

Figure 4. Schematic of dendrimer synthetic strategies A. Divergent growth B. Convergent growth ...

Dendritic layer copolymers have also been prepared via the hypercore approach,87 and by divergent growth from the periphery of convergently prepared dendrimers,446 or dendronized polymers.398 This layered dendritic architecture has been used by a number of groups to probe the nature of chirality. 

There are two main synthetic rontes used to prepare dendrim (1) divergent growth and (2) convergent growth. 

FIGURE 30.6 (a) The divergent growth method of dendrimers. (b) The convergent growth method of... 

Scheme 30.18 Accelerated synthesis of a fourth-generation bis-MPA dendrimer using CuAAC click coupling reactions in combination with esterification chemistry by the divergent growth approach. Reproduced with permission from Ref [132] 2007, The Royal Society of Chemistry.

Scheme 30.19 The rapid synthesis of a sixth-generation dendrimer using an orthogonal AB2 — CD2 divergent growth approach employing both thiol-ene and CuAAC click coupling reactions, (i) Thiol-ene coupling (ii) CuAAC (iii) Thiol-ene coupling (iv) CuAAC (v) Thiol-ene coupling (vi) CuAAC. Reproduced with permission from Ref [133] 2010, American Chemical Society.

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