Dementia neuroleptic malignant

Increased mortality in elderly w/ dementia-related psychosis Uses Schizophrenia Action Dopamine serotonin antagonist Dose Adults. 10-15 mg PO daily 5.25-15 mg for acute agitation Caution [C, -] Disp Tabs, inj SE Neuroleptic malignant synd,... 

A report found that even small doses of Risperdal (average dose of 1.7 mg/day) produced or worsened acute extrapyramidal reactions in one-third of an elderly population suffering from dementia (Baker, 1996). Among 41 patients, 6 developed new parkinsonism, 5 had a worsening of previous parkinsonism, one developed cervical dystonia, and one developed neuroleptic malignant syndrome while also taking Tegretol and Mellaril. 

Sechi, G., Agnetti, V., Masuri, R., Deiana, G., Pugliatti, M., Paulus, K., et al. (2000). Risperidone, neuroleptic malignant syndrome and probable dementia with Lewy bodies. Progress in Neuro-psychopharmacology and Biological Psychiatry, 24, 1043-1051. 

Delayed risperidone-induced neuroleptic malignant syndrome has been reported in a 27-year-old man after 21 months (108), and in a 17-year-old girl who took risperidone 0.5 mg bd (109). Risperidone-induced neuroleptic malignant syndrome has also been reported in a 63-year-old woman with probable Lewy body dementia, who had previously had an episode of neuroleptic malignant syndrome with trifluoperazine (110). 

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