Demeclocycline photosensitivity caused

Photosensitivity Tetracyclines, especially demeclocycline, may cause enhanced skin sensitivity to ultraviolet light. 

Demeclocycline has a spectrum of activity comparable to tetracycline but it may cause nephrogenic diabetes insipidus. It is also associated with a high incidence of photosensitivity. 

Before the introduction of specific vasopressin receptor antagonists, pharmacological treatments for hyponatremia centered on the use of loop diuretics and nonspecific inhibitors of vasopressin signaling, such as lithium carbonate and demeclocycline.11 The utility of such therapies has been limited by a range of sideeffects. Loop diuretic use can result in electrolyte imbalances and suffers from poor response predictability.11 Lithium carbonate suffers from a low therapeutic index and a risk of renal damage as well as limited effectiveness in many patients. Lithium carbonate has therefore been nearly completely supplanted by demeclocycline, a tetracycline antibiotic, in the treatment of chronic hyponatremia.12 Demeclocycline use is itself limited by its nephrotoxicity (particularly in cirrhotic patients), ability to cause reversible uremia, and ability to induce photosensitivity.1,11... 

The systentic administration of demeclocycline elicits photosensitization to ultraviolet light or sunlight. Minocycline causes vertigo and dizziness. The intravenous adntinistration of tetracyclines has been observed to cause venous thrombosis. 

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