Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Deltorphins spinal

The high-affinity GTPase activity in the mouse spinal cord is increased in a concentration-dependent manner by [D-Ala2]deltorphin II [82]. This increase of GTPase activity induced by [D-Ala2]deltorphin II is completely blocked by coincubation with a selective delta opioid receptor antagonist NTB [82]. [Pg.338]

An ITH injection of [D-Ala2]deltorphin II produces an acute antinociceptive tolerance [128], Concomitant pretreatment with lower doses of the PKC inhibitor calphostin C markedly prevents the development of acute tolerance to the ITH-administered [D-Ala2]deltorphin II-induced antinociception. On the other hand, the PKA inhibitor KT5720, has no effect on the development of acute tolerance to [D-Ala2]deltorphin II antinociception [128], It is therefore likely that PKC, but not PKA, plays an important role in the process of homologous desensitization of the spinal delta opioid receptor-mediated antinociception. [Pg.343]

See other pages where Deltorphins spinal is mentioned: [Pg.180]    [Pg.183]    [Pg.300]    [Pg.306]    [Pg.306]    [Pg.307]    [Pg.310]    [Pg.310]    [Pg.311]    [Pg.312]    [Pg.313]    [Pg.314]    [Pg.316]    [Pg.319]    [Pg.335]    [Pg.336]    [Pg.337]    [Pg.338]    [Pg.341]    [Pg.342]    [Pg.342]    [Pg.345]    [Pg.345]    [Pg.346]    [Pg.347]    [Pg.440]    [Pg.471]    [Pg.33]    [Pg.253]    [Pg.253]   
See also in sourсe #XX -- [ Pg.306 , Pg.336 , Pg.337 ]



SEARCH



Deltorphin

Deltorphins

© 2024 chempedia.info