Delta power

Barbier et al. (2004) investigated the effects of a highly selective and novel non-imidazole H3 receptor antagonist, 1, l-[4-(3-piperidin-l-yl-propoxy)-benzyl]-piperidine (JNJ-5207852), on sleep and wakefulness in mice and rats. Systemic injections of JNJ-5207852 (1-10 mg/kg, s.c.) increased the time spent in wakefulness with a concomitant decrease in NREM and REM sleep in both mice and rats. The overall increase in wakefulness was due to an increase in the number of wakefulness bouts. Spectral analysis of the EEG also revealed a reduction in total delta power following systemic injections of this compound (Barbier et ah, 2004). 

Mathematical analyses of EEG SWA have yielded quantitative information about the time course of accumulation and discharge of sleep need. The dynamics of the sleep/wake-dependent changes in delta power have been quantified with the use of computer simulations, and delta power can now be predicted in detail. The increase of sleep need during waking can be described by an exponentially saturating curve with a time constant (Tj) of 18.2 hr in humans (37) and 8.6 hr in... 

Figure 3 Time course of EEG delta power in SWS during baseline (BSL) and recovery (REC) after a 6 h SD regimen. AK = AKR/J C = BALB/c B6 = C57BL/6 BR = C57BR/cdJ D2 = DBA/2J 129 = 129/OLA. The baseline data presented on the left (open circles) are repeated on the right to facilitate comparison to delta power recorded during recovery after the 6-hr SD (closed circles). Triangles represent bins in which significant differences in delta power occur. (Modified from Ref. 52.)...

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Kava-kava is a well-established hypnotic drug with a rapid onset of effect, adequate duration of action and minimal morning after-effects. As mentioned previously, however, reports of serious hepatotoxicity with this preparation have led to its being banned in most countries worldwide [365]. Kava-kava extract produced a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with flunitrazepam, a BDZ utilized as hypnotic [366]. 

Significant differences of Delta power response were observed in three electrode channels, shown in Fig. 11.16. In the Fp2 and F3 channels, the mean of the difference is over zero at 90% and 88% confidence level, respectively, which shows that Pattern... 

Figure 11.16 Significant results of the Delta power corresponding to Patterns 1.1 and 1.2.

A significant difference of Delta power was observed at the F4 channel located in the right of the frontal lobe of the brain, as shown in Fig. 11.21. The mean of difference is over zero at 80% confidence level, which shows that Pattern 2.1 triggered higher Delta power than Pattern 2.2 in this location of the brain. 

Significant findings of people s Delta power response were observed in different areas of the brain as shown in Fig. 11.27. They include the Fp2 channel in the prefrontal lobe, F3, Fz and F4 channels all over the frontal lobe, the C3 channel in the left central... 

Significant differences of Delta wave power were observed in five electrode channels as shown in Fig. 11.33. They are the Fpl and Fp2 channels in the prefirontal lobe, the C4 channel at the right of the central sulcus, and the 01 and 02 channels over the occipital lobe. The mean of the difference in these channels is less than zero at 80% and 85% confidence levels, which shows that Pattern 4.1 evoked less Delta power than Pattern 4.2 in these locations of the brain. 

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