Delivery of Other Molecules

A number of other molecules may be delivered by electroporation oligonucleotides [20], ions [21, 22], dyes [23], and radioactive tracers [24]-just to mention a few. For in vivo injection it is important to consider the following. 

1) Washout of the molecule from tissue. Is it a very rapid process, for example, as seen for Cr-EDTA which has an extremely rapid renal clearance Or will the molecule remain in the target area much longer, as would be the case for proteins and larger nucleotides  

2) Charge of the molecule, which may affect uptake by electroporation at the cellular level, but charge may also lead to sequestrahon in the extracellular volume. An example of an oUgonucleohde class (peptide nucleic acid) and how charge may play an important role are given in Joergensen et al. [20]. 

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