Delivered Product Size Distribution and Morphology

Depending on the relative growth rates of the faces of a given crystalline product, it can be considered to grow in a one-, two-, or three-dimensional form. Pharmaceutical products from these respective growth types are shown in Fig. 4-25. 

Crystallization processes using either added or nucleated seed can be designed to manufacture product with a desired product size distribution. The following steps must be taken to achieve this goal  

The ultimate particle size distribution can be calculated by simple geometry. A simple calculation is shown in Table 4-2 for growth on 5 micron cubes at different seed/nucleate levels, for three-, two-, and one-dimensional growth. As noted in the note at the bottom 

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