Deiodinase type 2 gene

The Deiodinase Type 2 (D/02) Gene and Mental Retardation in Iodine Deficiency... 

Figure 7.4 The effect of bile acids on energy expenditure. Circulating bile acids bind to the G-protein-coupled receptor, TGR5 that stimulates increased cAMP-PKA activation and increased expression of type-2 iodothyronine deiodinase (D2). This response is sensitised by a high-fat diet. D2 converts thyroxine (T4) to active 3,5,3 -tri-iodothyronine (T3). T3 stimulates thyroid hormone receptor binding to target genes. This leads to altered expression of genes associated with energy balance, and increased energy expenditure.

The genes for all three deiodinases contain the TGA triplet in the coding region of the DNA, while the mRNA contains a UGA triplet at the corresponding position. Part of the coding sequence of type II deiodinase is shown in what follows. The entire protein consists of 266 amino acids. The codon resulting in selenocysteine is indicated by "SeC," where this amino acids resides in the context -glycine-serine-alanine-threonine-selenocysteine-proline-proline-phenylalanine-threonine- (Pallud et al., 1997) ... 

Figure 66.5 LD matrix generated from the Hapmap data phase II around the DI02 gene region. There are three reference genes in this 1 Mb region. They are NRXN3 (neurexin 3), DI02 (deiodinase, iodothyronine, type II) and C140RF145 (chromosome 14 open reading frame 145).

Type 3 deiodinase gene expression on the cardiovascular system, which implies a sophisticated mechanism of TH local bioavailability, opens the way to potentially interesting therapeutic perspectives involving novel molecular and pharmacological strategies in the field of HE... 

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