Degraded gelatin polyme

III. Degraded gelatin polymer- polygeline (3.5% in electrolyte solution HAEMACCEL)... 

Other important examples are blood and blood products, which are collected and processed in sterile containers, and plasma substitutes, for example dextrans and degraded gelatin. Dextrans, glucose polymers consisting essentially of (1 - 6) a-links, are produced as a result of the biochemical activities of certain bacteria of the genus Leuconostoc, e.g. L. mesenteroides (see Chapter 25). 

Degradable materials of biological origin are well known including, for example, crosslinked gelatin. Hyaluronic acid has been crosslinked and used as a degradable swelling polymer for biomedical applications. 

In summary, none of the individual components necessary for recombinant resilin curing were cytotoxic, and there were no leachables from the cured resilin that caused cell death. The cured resilin polymer was not a good surface for cell adhesion, but cells can survive and proliferate in the resilin on a gelatine bead. The curing of recombinant resilin in the presence of cells on beads has no effect on the cells ability to migrate and proliferate with new tissue formation. The resilin is seen to degrade with time, but it is believed that this could be controlled by the type and extent of cross-linking. 

---