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Degradation mechanism, worm

Mechanism of Action A benzimidazole carbamate anthelmintic that degrades parasite cytoplasmic microtubules, irreversibly blocks cholinesterase secretion, glucose uptake in helminth and larvae (depletes glycogen, decreases ATP production, depletes energy). Vermicidal. Therapeutic Effect Immobilizes and kills worms. Pharmacokinetics Poorly and variably absorbed from GI tract. Widely distributed, cyst fluid and including cerebrospinal fluid (CSF). Protein binding 70%. Extensively metabolized in liver. Primarily excreted in urine and bile. Not removed by hemodialysis. Half-life 8-12 hr. [Pg.23]

See other pages where Degradation mechanism, worm is mentioned: [Pg.168]    [Pg.169]    [Pg.170]    [Pg.173]    [Pg.1344]    [Pg.373]    [Pg.19]    [Pg.20]    [Pg.431]    [Pg.410]    [Pg.174]    [Pg.15]    [Pg.38]    [Pg.180]    [Pg.803]    [Pg.259]   


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Degradation mechanism

Degradative mechanisms

Worms

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