Deferoxamine acute iron intoxication

Deferoxamine (Desferal ) has a specific ability to chelate iron and is useful in treating acute iron intoxication. Deferoxamine can be administered... 

Deferoxamine is widely used for treatment of both acute iron intoxication and iron-overload anemia. Recently, it has been used in trials of malaria treatment. 

Treatment of acute iron intoxication Immediate treatment is necessary and usually consists of removal of unab.sorbed tablets from the gut. correction of acid-ba.se and electrolyte abnormalities, and parenteral administration of deferoxamine, which chelates circulating iron. 

Clinical use Deferoxamine is used parenterally in the treatment of acute iron intoxication. 

F. Use in pregnancy. FDA category C (indeterminate). Although deferoxamine is a teratogen in animals, it has relatively poor placental transfer, and there is no evidence that short-tenn treatment is harmful in human pregnancy (see p 405). More importantly, failure to treat a serious acute iron intoxication may result in maternal and fetal morbidity or death. 

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See also in sourсe #XX -- [ ]

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