Deepwater sponges

The Pacific deepwater sponge Poecillastra laminaris contained annasterol sulfate (578), which had glucanase inhibitory activity [469]. 

Characterization of lndolo[3,2-a]carbazoles from a Deepwater Sponge of the Genus Asteropus... 

Wright and coworkers [74] reported the isolation and characterization of two indolo[3,2-a]carbazole alkaloids from a deepwater sponge of the genus Asteropus collected in New Zealand waters. Doublets observed in the 6 Hz optimized HMBC spectrum allowed the assignment of proton... 

Gross, H., Reitner, J., and Konig, G.M. (2004) Isolation and structure elucidation of azoricasterol, a new sterol of the deepwater sponge Macandrewia azorica. Naturwissenschaften, 91, 441-446. 

Kashman, Y, Hirsch, S., Koehn, F., and Cross, S. (1987) Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge. Tetrahedron Lett., 45, 5461-5464. 

Like the prianosins and the discorhabdins, the batzellines and isobatzellines are sulfides with a pyrroloquinone skeleton [22]. A deepwater Batzella sponge contained the alkaloids, batzellines A (457) and B (458), which possess methyl sulfide groups. The structure of... 

A was successfully obtained in culture from the bacterium Micromonospora sp. of the deepwater Indonesian sponge Acanthostrongylophora suggesting the possibility of supplying the compound by fermenting this... 

Secobatzelline A and secobatzelline B were isolated from a deepwater marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P388 and A549 cell lines [42]. 

AphrocaUistin (106), a cytoxic, adenine-substituted bromotyrosine-derived metaboUte of the deepwater Hexactinellida sponge A. beatrix, was isolated and characterized spectroscopically and via synthesis by Wright and... 

Gunasekera, S.P., Pomponi, S.A., and McCarthy, P.J. (1994b) Discobahamins A and B, new peptides from the Bahamian deepwater marine sponge Discodermia sp. /. Nat. Prod.. 57, 79-83. 

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