Nucleobase hydroperoxides, decomposition

A. Stable DNA Oxidation Products Arising from Nucleobase Hydroperoxide Decomposition... 

Nucleic adds, protein cross-links, 974-5 Nucleobase hydroperoxides, decomposition, 918, 975-7 Nucleophiles... 

Addition of a radical to the C6-position of thymine residues in DNA generates the C5-thymine radical 74 (Scheme 8.27). Reaction with molecular oxygen, followed by reduction, yields the hydroperoxide 75. Decomposition of the hydroperoxide ultimately yields the hydantoin nucleobase 78 via the ring-opened derivatives 76 and 77 ti,2 for the decomposition of 75 in aqueous solution is slow, with a 9 h for the tra i-isomer and 20 h for the c -isomer of the nucleoside)... 

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See also in sourсe #XX -- [ ]

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