Death phase, description

The model was adapted from Kontoravdi et al. (2005) for cell growth/death, nutrient uptake, and major metabolism. The model was further developed to include description of cell cycle sub-populations. The cell cycle representation was based on the yeast model of Uchiyama Shioya (1999) and the tumour cell model of Basse et al. (2003). Eq.(l)-(4) express viable cell concentration(Xv[cell L" ]) in terms of cells in Gq/Gi, S, and G2/M phases. As a simplification in notation, Gq/Gi cells will be indicated as G unless otherwise stated. Xoi, Xs, X02/M [cell L" ] are concentrations of viable cells in Gq/Gi, S, and G2/M phase, respectively, whereas Fo ,[L h" ] is the outlet flowrate. F[L] is the cell culture volume b, ki, k [h" ] are the transition rates of cells from Gi to S, S to G2, and M to Gi respectively and /[Pg.110]

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