De novo design of proteins

Richardson JS, Richardson DC. The de novo design of protein structures. Trends Birx hem Sci 1989 14 304-309. 

De novo design of proteins with pre-specified enzymatic activity is one of the most complex goals of protein engineering. So far only a few resnlts have been reported, but they are extremely interesting because they do prove that we are at the level where our insight into protein structure is sufficiently advanced to allow for de novo enzyme design. 

Sander, C. (1991) De novo Design of Proteins. Current Opinion in Structural Biology,... 

Klebe, G. (1994) The use of composite crystal-field environments in molecular recognition and the de novo design of protein ligands. J. Mol. Biol. 237,221-235. 

The current status of the problem of de novo design of proteins and prospects in the area including energy landscape theory of protein folding, atomistic and minimal... 

Richardson, J.S. and Richardson, D.C. (1990). The de novo design of protein stmctures. In Proteins Form and Function. R.A.Bradshaw and M.Pnrton, eds. (Cambridge Elsevier Trends Jonmals), pp. 173 182. 

The introduction of molecular biological methods in protein biochemistry has achieved steady progress towards the rational engineering and de novo design of proteins for novel functions, and several... 

G. Klebe,. Mol. Biol., 237,212 (1994). The Use of Composite Crystal-Field Environments in Molecular Recognition and the De Novo Design of Protein Ligands. 

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