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DCC/DMAP

The 2-iodobenzoate is introduced by acylation of the alcohol with the acid (DCC, DMAP, CH2CI2, 25°, 96% yield) it is removed by oxidation with CI2 (MeOH, H2O, Na2C03, pH > 7.5). ... [Pg.111]

RCO.H, R OH, DCC/DMAP, Et20, 25°, 1-24 h, 70-95% yield. This method is suitable for a large variety of hindered and unhindered acids and alcohols. ... [Pg.228]

Fluorenylmethyl esters of A -protected amino acids were prepared using the DCC/ DMAP method (50-89% yield) or by imidazole-catalyzed transesterification of... [Pg.234]

The Dppe group was developed for carboxyl protection in peptide synthesis. It is formed from an N-protected amino acid and the alcohol (DCC, DMAP, 3-12 h, 0°, It). It is most efficiently cleaved by quatemization with Mel followed by treatment with fluoride ion or K2CO3. The ester is stable to HBr/AcOH, BF3 Et20, and CF3CO2H. ... [Pg.245]

This ester was designed as a base-labile protective group. Monoprotection of aspartic acid was achieved using the DCC/DMAP protocol. Cleavage is... [Pg.403]

Dimethyl-3-pentanoL DCC, DMAP, CH2CI2, 4 h. This group was developed as an improvement over the use of cylcohexanol for aspartic acid protection during peptide synthesis. ... [Pg.409]

This amide is readily prepared from the acid chloride (Pyr, rt, 1 h, 77-86% yield) or the acid (DCC, DMAP, CH2CI2, rt, 1 h, 88% yield). Treatment of the amide with camphorsulfonic acid forms an A-acylindole. The acid can be regenerated from the A-acylindole by Li0H/H202/THF/H20 or NaOH/MeOH. Alternatively, it can be transesterified with MeOH/TEA, converted to an amide, by heating with an amine or converted to an aldehyde by DIB AH (62-85% yield). ... [Pg.448]

Fig. 29 Microwave-promoted multicomponent synthesis of polysubstituted thiophenes on soluble PEG support. Reagents and conditions a NCCH2OOH, DCC, DMAP, CHCI3, MW 130 W, 5 min b RCOCH2R, S8, diisopropylethylamine, MW 130 W, 15 min c R"COCl, di-isopropylethylamine, 0 °C to rt, 3 h d 1% KCN in CH3OH, o.n. R = H or alkyl R = alkyl or acyl R" = CH3, Ph... Fig. 29 Microwave-promoted multicomponent synthesis of polysubstituted thiophenes on soluble PEG support. Reagents and conditions a NCCH2OOH, DCC, DMAP, CHCI3, MW 130 W, 5 min b RCOCH2R, S8, diisopropylethylamine, MW 130 W, 15 min c R"COCl, di-isopropylethylamine, 0 °C to rt, 3 h d 1% KCN in CH3OH, o.n. R = H or alkyl R = alkyl or acyl R" = CH3, Ph...
Esterification of 22 with diol 24 (DCC/DMAP/BtOH) gave 29 in 84% yield (Fig. 12) and subsequent hydrolysis of the f-butyl ester group under acidic conditions afforded the third-generation carboxylic acid 23. All of the spectroscopic... [Pg.98]

Fig. 11. Synthesis of fullerodendrons 21 and 22. Reagents and conditions (i) DCC, DMAP, CH2CI2,0 °C to room temperature (83%) (ii) Cgo, DBU, b, toluene, room temperature (59%) (iii) CF3CO2H, CH2CI2, room temperature (99%) (iv) 24, DCC, DMAP, BtOH, CH2CI2,0 °C to room temperature (90%) (v) CF3CO2H, CH2CI2, room temperature (99%)... Fig. 11. Synthesis of fullerodendrons 21 and 22. Reagents and conditions (i) DCC, DMAP, CH2CI2,0 °C to room temperature (83%) (ii) Cgo, DBU, b, toluene, room temperature (59%) (iii) CF3CO2H, CH2CI2, room temperature (99%) (iv) 24, DCC, DMAP, BtOH, CH2CI2,0 °C to room temperature (90%) (v) CF3CO2H, CH2CI2, room temperature (99%)...
Fig. 12. Synthesis of fuUerodendron 23. Reagents and conditions (i) 24, DCC, DMAP, BtOH, CH2CI2,0 °C to room temperature (90%) (ii) CF3CO2H, CH2CI2, room temperature (99%)... Fig. 12. Synthesis of fuUerodendron 23. Reagents and conditions (i) 24, DCC, DMAP, BtOH, CH2CI2,0 °C to room temperature (90%) (ii) CF3CO2H, CH2CI2, room temperature (99%)...
DCC, DMAP in CH2CI2 followed by reaction with functionalized isoquinoline... [Pg.80]

Macrolactonization of co-hydroxyl acids using a combination of DCC, DMAP and DMAP-HCl. [Pg.327]

See other pages where DCC/DMAP is mentioned: [Pg.97]    [Pg.244]    [Pg.249]    [Pg.251]    [Pg.168]    [Pg.401]    [Pg.404]    [Pg.412]    [Pg.416]    [Pg.431]    [Pg.699]    [Pg.67]    [Pg.695]    [Pg.102]    [Pg.288]    [Pg.27]    [Pg.28]    [Pg.247]    [Pg.345]    [Pg.346]    [Pg.293]    [Pg.133]    [Pg.223]    [Pg.80]    [Pg.244]    [Pg.25]    [Pg.319]    [Pg.473]    [Pg.327]    [Pg.23]   
See also in sourсe #XX -- [ Pg.431 ]



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