Databases adverse event estimation

A retrospective analysis of insurance claims (MarketScan Commercial Claims and Encounters database, minimum of 2-year enrolment, at least two pregnancy-related medical claims, 2005-2009) of 800,000 women (15 4 years of age) representing 1 million pregnancies developed population-based estimates of the prevalence of TTX, ATD use, and infant anomalies in the presence and absence of ATD use and risk of adverse events in this population of pregnant women [37 ]. 

The Institute of Medicine (lOM) estimates that between 44,000 and 98,000 deaths annually in the U.S. result from medical errors. While there is some debate about this estimate, it is clear that medication errors are common and result in significant adverse effects, including death. Databases of anonymously reported errors are maintained jointly by the Institute for Safe Medication Practices (ISMP), the U.S. Pharmacopeia Medication Errors Reporting Program (USP MERP), and the FDA s MedWatch program. Adverse drug events occm in 3% of hospitalizations, and this number is larger for special populations such as those in pediatric and neonatal intensive care units. 

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