Dapsone tablets

The patient s daily dose is 154 mg (2 mg X 77 kg). Dapsone tablets are available as 50 mg so the patient requires 3 tablets of dapsone 50 mg on a daily basis. Hence 90 tablets (3 X 30 days) of dapsone 50 mg should be dispensed to the patient. 

The patient is prescribed 150 mg of dapsone On hand are 50-mg tablets. The nurse administers... 

Dapsone 50-1 00-mg tablet by mouth once a day Hepatotoxicity Myelosuppression Nephritis... 

A woman with a body weight of 77 kg is prescribed dapsone 2 mg/kg daily. Dapsone is available as 50 mg tablets. The number of tablets to be dispensed for 30 days supply is ... 

The buffer in didanosine tablets and powder interferes with absorption of indinavir, delavirdine, atazanavir, dapsone, itraconazole, and fluoroquinolone agents therefore, administration should be separated in time. Serum levels of didanosine are increased when -administered with tenofovir or ganciclovir, and are decreased by atazanavir, delavirdine, ritonavir, tipranavir, and methadone (Table 49-4). 

The original formulation, a buffered powder, has been replaced by chewable and dispersible buffered tablets with greater bioavailability (30-40%) a new enteric-coated formulation further improves patient convenience and tolerability. Since the chewable tablets contain both phenylalanine (36.5 mg) and sodium (1380 mg), caution should be exercised in patients with phenylketonuria and those taking sodium-restricted diets. Didanosine should be taken on an empty stomach and, because of the buffered formulation, should be administered at least 2 hours after administration of drugs requiring acidity for optimal absorption (eg, ketoconazole, itraconazole, dapsone). 

Sahai J, Garber G, Gallicano K, Oliveras L, CameronDW. Effects of the antacids in didanosine tablets on dapsone pharmacokinetics. Arm Intern Med( 995) 123,584-7. 

A 19-year-old man with a depressive disorder, taking olanzapine, lorazepam, and aripipra-zole, took an intentional overdose of40-45 tablets of dapsone 100 mg (a total of 4—4.5 g). He became drowsy but was conscious and responded to oral commands. There were signs of cyanosis and sinus tachycardia. The serum methemoglobin concentration was increased at... 

For assay powder twenty tablets, weigh a quantity to contain about 0 25 g of dapsone, dissolve in 30 ml of a mixture of equal volumes of dilute hydrochloric acid and water and titrate with 0 1 M sodium nitrite as above. 

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