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Daphnane diterpenoids

Resiniferatoxin (RTX) is a daphnane diterpenoid contained in the irritant latex of some succulent African Euphorbias. Its total synthesis has been described as a 40 step asymmetric synthesis (Wender et al., 1997 see below), but for clinical use RTX isolated from Euphorbia resinifera. [Pg.511]

The biogenetic structural relationships and structure-activity relationships of the diterpenoid skin irritants and co-carcinogens of the Euphorbiaceae and Thymelaceae have been described in a number of reviews.Baliospermum montanum (Euphorbiaceae) contains the orthoester montanin (111) and baliospermin (112) together with some 12-deoxyphorbol-13-esters. A number of new highly irritant 1-alkyl-daphnane orthoester derivatives [(113) and the corresponding 3-ketone] have been obtained from the Thymelaceae. The Chinese... [Pg.178]

See other pages where Daphnane diterpenoids is mentioned: [Pg.543]    [Pg.121]    [Pg.122]    [Pg.91]    [Pg.60]    [Pg.543]    [Pg.121]    [Pg.122]    [Pg.91]    [Pg.60]    [Pg.192]    [Pg.246]    [Pg.179]    [Pg.346]    [Pg.984]    [Pg.200]    [Pg.984]    [Pg.281]   


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Daphnane diterpenoids synthesis

Daphnane diterpenoids via Cope rearrangement

Daphnanes

Diterpenoid

Diterpenoides

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