Danish University Antidepressant Group

Danish University Antidepressant Group Citalopram clinical effect profile in comparison with clomipramine a controlled multicenter study. Psychopharmacology 90 131-138, 1986... 

TCAs derive their name from their chemical structure aU tricyclics have a three-ring nucleus. Currently, most clinicians are moving away from using TCAs as first-line drugs relative to the newer antidepressants, they tend to have more side effects, to require gradual titration to achieve an adequate antidepressant dose, and to be lethal in overdose. Some data suggest that TCAs may be more effective than SSRIs in the treatment of major depression with melancholic features (Danish University Antidepressant Group 1990 Perry 1996) however, many skilled clinicians and researchers continue to prefer the newer antidepressants, even for patients with melancholia, for the aforementioned reasons. Newer medications that affect both norepinephrine and serotonin (e.g., venlafaxine and mirtazapine) also may have superior efficacy in severely iU depressed patients or when remission is defined as the outcome (Thase et al. 2001). 

Danish University Antidepressant Group Paroxetine a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 18 289-299, 1990... 

Stage KB, Kragh-Sorensen PB Danish University Antidepressant Group. Age-related adverse drug reactions to clomipramine. Acta Psychiatr Scand... 

Licht RS, Nielson JN, Gram LF, Vestergaard P, Bendz H. Lamotrigine versus lithium as a maintenance treatment in bipolar I disorder an open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group. Bipolar Disord 2010 12(5) 483-93. 

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