Danish EPAs Approach

In Denmark, health-based quality criteria are set for chemical substances in soil, drinking water, and ambient air according to principles laid down in a guidance document from the Danish Environmental Protection Agency (D-EPA 2006). The principles laid down in the guidance document are based on an extensive review addressing the hazard assessment of chemicals, including application of assessment factors (Nielsen et al. 2005). 

For threshold effects, a Tolerable Daily Intake (TDI) is calculated by dividing the NOAEL (or LOAEL) for the critical effect(s) with an overall UF. The current practice according to the D-EPA in relation to the setting of quality criteria for chemical substances in soil, drinking water, and ambient air is to divide the overall UF into three categories (D-EPA 2006)  

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