D Structure of Human Pancreatic Lipase

The determination of fhe 3-D structure of HPL by Winkler et al. [13] confirmed fhe existence of two distinct domains in pancreatic lipase a larger N-terminal domain comprising residues 1-336, and a smaller C-terminal domain made up of residues 337—449. The high degree of amino acid sequence homology observed wifhin fhe hpase gene family supports fhe view fhat this particular architecture is also common to Upoprotein Upase and to hepatic hpase [14—19]. 

The /1-sandwich C-terminal domain of pancreatic lipase is necessary for colipase binding to occur, as shown in the 3-D structure of the HPL-porcine procolipase 

Horse pancreatic hpase has been solved and is almost identical to HPL [34]. 

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