D9-Tetrahydrocannabinol

Marijuana contains a psychoactive resin called D9 tetrahydrocannabinol (THC) and cannabinol. Most resin is found in the flowering female plant. When smoked or ingested it produces a feeling of relaxation, euphoria, and happiness. Other possible effects include poor concentration and decreased reaction time. Used medically under the names dronabinol and marinol, it has been prescribed as an antiemetic and as an appetite stimulant and has also been used... 

Chen J, Paredes W, Li J, Smith D, Lowinson J, Gardner E (1990) D9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology (Berl) 102 156-162... 

Gardner EL, Paredes W, Smith D, Donner A, Milling C, Cohen A, Morrison D (1988) Facilitation of brain stimulation reward by D9-tetrahydrocannabinol. Psychopharmacology (Berl) 96 142-144... 

Lepore M, Liu X, Savage V, Matalon D, Gardner EL (1996) Genetric differences in D9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. Life Sci 58 365-0372... 

Takahashi RN, Singer G (1979) Self-administration of D9-tetrahydrocannabinol by rats. Pharmacol Biochem Behav 11 737-740... 

Bac, R, Pages, N., Herrenknecht, C. and Paris, M. (1998) Measurement of the three phrases of muricidal behavior induced by D9-tetrahydrocannabinol in isolated, fasting rats. Physiol Behav, 63 815-20. 

Carlini, E.A. (1977) Further studies of the aggressive behavior induced by D9-tetrahydrocannabinol in REM sleep-deprived rats. Psychopharmacology (Berl), 53 135-45. 

Pertwee RG (2005) Pharmacological actions of cannabinoids. In Pertwee RG (ed), Cannabinoids, Handbook of experimental pharmacology, vol, 168, Springer, Berhn, pp 1-51 Pertwee RG (2007) The diverse CBl and CB2 receptor pharmacology of three plant cannabinoids D9-tetrahydrocannabinol, cannabidiol and D9-tetrahydrocannabivarin, Br J Pharmacol (Sep 10 Epub ahead of print)... 

An example of a CEC analysis of an illicit drug was shown by Lurie and collaborators [134], In this study, a standard mixture of seven cannabinoids was separated, and this test mixture was then compared with concentrated hashish and marijuana extracts (Figure 5.26). The cannabinoid standards used were cannabigerol (CBG), cannabidiol (CBD), cannabinol (CBN), A-9-tetrahydrocannabinol (d9-THC), A-8-tetrahydrocannabinol (d8-THC), cannabichromene (CDB), and A-9-tetrahydrocannabinolic acid (d9-THCA-A), with dimethyl sulfoxide (DMSO) as the neutral marker. A Hypersil C18 column (3 (im dp) was used. The column inner diameter was 100 pm and had a total length of 49 cm, and the effective length was 40 cm. UV detection was conducted at 210 nm. The run buffer was 75% ACN and 25% 25 mM phosphate buffer pH 2.57. The applied voltage was 30 kV, and the column temperature was kept at 20°C. 

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