Cytotoxicity activities against central nervous system

Nemorosone and its methyl derivatives as mixture were evaluated against the human cervix carcinoma (HeLa), the human larynx carcinoma (HEp-2), prostate carcinoma (PC-3) and central nervous system carcinoma (U-251) cell lines [94]. Cuesta-Rubio et al. found that the natural product nemorosone was active against the four cell lines (IC50 values of 3.3, 3.1, 7.2 and 3.9 pM, respectively). When the mixture of methyl derivatives was used, the required concentration to reach IC50, in the cellular lines, was between ten and thirty times more concentrated. These results suggest that the presence of the keto-enolic equilibrium in nemorosone plays an important in its cytotoxicity. 

The effects of the molecular structure of phosphonium- and ammonium-based ILs and ILBSs side chain counterion BF , PF ,Tf2N") on the antitumor activity and cytotoxicity were evaluated in vitro for the first time for the NCI-60 human tumor cell lines. All surface-active compounds (see Rg. 4.12) were found to be active against leukemia, melanoma, lung, colon, kidney, ovary, breast, prostate, and central nervous system cancer cells the tetra(l-butyl)ammonium TfjN" was not [87]. 

---