Cytostatic agents cisplatin

Diamminedichloridoplatinum(II) can exist as the two isomers shown below. Isomer A is the cytostatic agent cisplatin and usually described by the stereo-descriptor cis, whilst its cy to statically inactive diastereomer B is assigned the stereodescriptor trans. 

Cisplatin is a platinum complex (platinum dichloride and two ammonia molecules) used as a cytostatic agent against cancer. The molecule cross-links DNA strands, thus leading to cell death. 

Lipiodol (= iodized ester of poppyseed oil) used as a contrast medium for lymphography accumulates selectively in the tumour over a longer period of time. As a result, local-interventional (oily) lipiodol chemotherapy (TOCE) was developed. Lipiodol acts as a carrier for the admixed cytostatic agents, so that the latter retain their effect in the tumour long-term in a high (systematically unacceptable) dose. Hereby, cisplatin or epidox-orubicin (101) is emulgated in lipiodol. It was possible to achieve 1-year survival rates of 36-55%. Other cytostatics did not prove to be any more effective. 

A number of cytostatic drags, including cisplatin, are carcinogenic. NADH is able to protect cells from the carcinogenic effects of these chemotherapeutic agents. Hence ENADA, the stabilized oral form of NADH, may present a safe, nontoxic, biological supplement for prevention of cancer. 

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