Cytolytic peptides

The characteristics and possible mechanisms of action of cytolytic peptides isolated from sea anemones during the past 20 years are described. These agents fall into three categories (1)... 

Cytolytic peptides derived from 16 species of anemones currently comprise this group (Table I). It is likely that as additional species are examin in the future... 

Kuhn-Nentwig, L. (2003) Antimicrobial and cytolytic peptides of venomous arthropods. Cell Mol. Life Sci. 60(12), 2651-2668. 

A newly defined group of antimicrobial and cytolytic peptides from spider venom. See Kozlov, S.A., Vassilevski, A.A., Feofanov, A.V. et al., Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity, J. Biol. Chem. 281, 20983-20992, 2006. 

Hemolysin from S. aureus. A 26-residue cytolytic peptide is secreted by pathogenic strains of Staphylococcus aureus its interactions with lipid bilayers have been well characterized (216). A dose-response curve with a slope of 7 suggests that aggregates of the toxin form channels. Two substates were observed one with conductances of 70 and 100 pS the other with 420- and 470-pS levels. NMR in methanol indicates (217) a well-ordered... 

Wang R, Braughton KR, Kretschmer D et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 2007 13 1510-1514. 

Soman, N.R., Baldwin, S.L., Hu, G., etal. (2009). Molecularly targeted nanocairiers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth. J Clin Inv 119, 2830-2842. 

Cytolytic peptides and protein toxins from sea anemones (Anthozoa Actinaria). Anderluh, G.A., Macek, P. (2002), 40, 111-124. 

Bemheimer, A. W. and Rudy, B., 1986, Interactions between membranes and cytolytic peptides. Biochim. Biophys. Acta 864 123-141. 

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