Cystic fibrosis ibuprofen

Age does not significantly affect plasma concentrations or disposition of ibuprofen however, investigators have determined that the onset of antipyresis and maximum antipyretic effect is greater in children less than one year old as compared to children older than 6 years [43]. The authors hypothesized that this accelerated response was related to the greater relative body surface area of the young child. It should be noted that cystic fibrosis patients do have a higher clearance of ibuprofen [43a]. 

Kearns GL, Murry DJ, Oermann C, Gaedigk A, Sock-nider M, Seilheimer DK et al. Ibuprofen pharmacokinetics in cystic fibrosis association with CYP2C9 genotype. Pediatr Pulmonol 1999 28 S19 208. 

Aspirin and ibuprofen Section 12.5.2 Digitalis and congestive heart failure Section 13.2.3 Multidrug resistance and cystic fibrosis Section 13.3 Protein kinase inhibitors as anticancer drugs Section 15.5.1... 

An adolescent with cystic fibrosis developed renal insufficiency and severe vestibular toxicity after treatment with gentamicin and standard-dose ibuprofen (72). A low intravascular volume was a possible contributing factor. 

High dosages of ibuprofen for 4 years were used in 41 patients with cystic fibrosis to slow progression of lung disease and only two adverse effects (conjunctivitis and epistaxis) were drug-related (SEDA-20, 93). 

Kovesi TA, Swartz R, MacDonald N. Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis. N Engl J Med 1998 338(l) 65-6. 

Konstan MW, Byard PJ, Hoppel CL, el al. Effecl of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 1995 332 848-854. 

Cystic fibrosis patients may suffer from pulmonary inflammation that is treatable with NSAIDs. In 38 pediatric patients suffering from cystic fibrosis, the enantioselective pharmacokinetics of ibuprofen have been studied (Table 1) [288]. The S R mean ratio of concentrations was 2.0 in... 

Dong, J.Q. Ni, L. Scott, C.S. Retsch-Bogart, G.Z. Smith, P.C. Pharmacokinetics of ibuprofen enantiomers in children with cystic fibrosis. J. Clin. Pharmacol. 2000, 40, 861-868. 

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