Cystic fibrosis goals

This complex analysis would be in vain if one did not have some criterion for knowing when the goal of finding the cystic fibrosis gene was reached. This is where clues from the physiological nature of the condition became useful. In a brilliant strategy a cDNA library was prepared from... 

These trials evaluated different therapies and utilized several differences in study design, making comparisons difficult. Additionally, the goals of therapy and the endpoints that were measured differed significantly. Controlled studies evaluating the use of inhaled antibiotics began to appear in the 1980s. These studies addressed primarily their use as suppressive therapy, and many were performed in patients with cystic fibrosis. 

Anionic species are well known to play a fundamental role in numerous biological and chemical processes. Many biologically important species are anionic such as nucleic acids and the majority of enzyme substrates. Anions also play a role in diseases such as cystic fibrosis, which is caused by the misregulation of Gl ion channels. In the environment, pollutant anions such as NOs and P04 can cause the eutrophication of waterways. In view of this, the design of receptors which can selectively bind, extract, and/or sense anions is an important goal, and has become the focus of a great deal of current research interest. 

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