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Cysteinylglycine conjugates

Anni H, Pristatsky P, Israel Y (2003). Binding of acetaldehyde to a glutathione metabolite mass spectrometric characterization of an acetaldehyde-cysteinylglycine conjugate. Alcoholism, Clin. Exper. Res. 27 1613-1621. [Pg.441]

Fig. 11.5. Mechanism of hydrolytic dechlorination of mechlorethamine (11.31, R = Me) and other antitumor nitrogen mustards [65] [66]. Also shown is the mechanism of the nonenzymat-ic conjugation with reduced glutathione (GSH, L-glutamyl-L-cysteinylglycine). Fig. 11.5. Mechanism of hydrolytic dechlorination of mechlorethamine (11.31, R = Me) and other antitumor nitrogen mustards [65] [66]. Also shown is the mechanism of the nonenzymat-ic conjugation with reduced glutathione (GSH, L-glutamyl-L-cysteinylglycine).
These data provide unambiguous proof of structure for three metabolites of efavirenz, the major metabolite 8-O-glucuronide conjugate, (9), the novel hydroxylated cyclopropyl, 8-O-sulfate, cysteinylglycine di-conjugate (8), and... [Pg.106]

The other metabolites are also mercaptides (C32, J5) and are probably conjugates of cysteine, cysteinylglycine, and cysteinylglutamate. Tbe presence of a diglutathione conjugate has also been reported (J5). [Pg.321]

Figure 6 1D and TOCSY HPLC-NMR spectra of the 8-0-sulfate, cysteinylglycine di-conjugate of efavirenz. [Pg.309]

See other pages where Cysteinylglycine conjugates is mentioned: [Pg.102]    [Pg.1496]    [Pg.99]    [Pg.534]    [Pg.331]    [Pg.332]    [Pg.308]    [Pg.102]    [Pg.1496]    [Pg.99]    [Pg.534]    [Pg.331]    [Pg.332]    [Pg.308]    [Pg.356]    [Pg.55]    [Pg.104]    [Pg.243]    [Pg.311]    [Pg.277]    [Pg.249]    [Pg.322]    [Pg.180]    [Pg.462]    [Pg.541]    [Pg.444]    [Pg.172]    [Pg.629]    [Pg.55]   


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Cysteinylglycine

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