Donepezil CYP2D6 inhibitors

Donepezil is metabolized in the liver by CYP2D6 and CYP3A4. Selective serotonin re-uptake inhibitors (SSRIs), such as paroxetine, are potent inhibitors of CYP2D6. Mood disorders are common in patients with Alzheimer s disease, and SSRIs are used in these patients and can increase the plasma concentration of donepezil, increasing the risk of severe adverse reactions. 

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