CYP2 family

The CYP2 family is the largest CYP family in humans and it comprises about 16 functional genes and 11 pseudogenes. 

CYP2. The CYP2 family contains isoforms from at least live subfamilies, 2A, 2B, 2C, 2D, and 2E, which contribute significantly to the drug metabolism. Recognized members of each subfamily are enumerated and a brief description of the major contributor from each follows. 

Lewis, D.F.V. Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes. Arch. Biochem. Biophys. 2003, 409,... 

Lewis, D. F. (2002) Homology modelling of human CYP2 family enzymes based on the CYP2C5 crystal structure. Xenobiotica 32, 305-323. 

CYP2E1 is the only member of the CYP2E family in most mammals with the exception of rabbits. Substrates for this family tend to be of small molecular weight and include ethanol, carbon tetrachloride, benzene, and acetaminophen. In contrast to many other inducible CYP families, CYP2E1 is regulated by a combination of increased transcription levels and increased message and protein stabilization. 

It has long been known that the regulation of CYP2 genes in fish differs from that in mammals. Although fish possess CYP2-family genes , they have been... 

Lewis DF. Quantitative structure-activity relationships (QSARs) for substrates of human cytochromes P450 CYP2 family enz5mies. Toxicol In Vitro 2004 18 89-97. 

Table 1.3 Drugs affecting or metabolised by the CYP2 family of cytochrome P450 isoenzymes...

Du L, Hoffman SM, Keeney DS (2004) Epidermal CYP2 family cytochromes P450. Toxicol Appl Pharmacol 195 278-287... 

---