Cyclosporine derivative

Price S L, R J Harrison and M F Guest 1989. An Ab Initio Distributed Multipole Study of the Electrostatic Potential Around an Undecapeptide Cyclosporin Derivative and a Comparison with Point Charge Electrostatic Models. Journal of Computational Chemistry 10 552-567. 

Improving free fraction continues to be a goal in the anti-infective area, particularly in areas where animal efficacy models are not readily available. The importance of adequate free fraction was noted in publications describing a series of HIV integrase inhibitors [52], the HCV protease inhibitor VX-950 [53], a series of cyclosporine derivatives active against HCV [54], and a series of antibacterial MurB inhibitors [55]. 

Potler M, Wolf A, and Cambar J. Comparative study of cyclosporin A, cyclosporin G, and the novel cyclosporin derivative IMM 125 In Isolated glomeruli and cultured rat mesangial cells a morphometric analysis. Nephrol Dial Transplant 13 1406-1411,1998. 

Hiestand PC, Graber M, Hurtenbach U, Herrmann P, Cammisuli 5, Richardson BP, Eberle MK, Donatsch P, Ryffel B, Borel JF. New cyclosporine derivative SDZ IMM 125 in vitro and in vivo pharmacologic effects and toxicologic evaluation. Transplant Proc... 

Kawai, R., Lemaire, M., Steimer, J.-L., Bruelisauer, A., Niederberger, W. and Rowland, M. (1994) Physiologically-based pharmacokinetic study on a cyclosporine derivative, SDZ IMM 125. Journal of Pharmacokinetics and Biopharmaceutics, 22, 327-365. 

Watanabe, T., N. Kokubu, S.B. Charnick, M. Naito, T. Tsuruo and D. Cohen. Interaction of cyclosporin derivatives with the ATPase activity of human P-glycoprotein. Br. J. Pharmacol. 122 241-248, 1997. 

McEwen ML, Springer JE (2005) A mapping study of caspase-3 activation following acute spinal cord contusion in tats. J Histochem Cytochem 53 809-819 McEwen ML, Sullivan PG, Springer JE (2007) Pretreatment with the cyclosporin derivative, NIM811, improves the function of synaptic mitochondria following spinal cord contusion in rats. J Neurotrauma 24 613-624... 

Patchett A A, White RF, Goegelman RT. A new cyclosporin derivative with modified 8-amino acid. U.K. Patent Application BG 2 206 119 A June 20,1988. 

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