Cyclosporin lupus nephritis

Clinical trials have revealed that diseases that are related directly to excessive TNF production, such as septic shock, GVHD, and lupus nephritis, may be amenable to treatment either with anti-TNFa antibodies or with antiinflammatory agents that reduce TNF production, such as cyclosporin A and steroids. ... 

Fu LW, Yang LY, Chen WP, Lin CY. Clinical efficacy of cyclosporin a ne-oral in the treatment of paediatric lupus nephritis with heavy proteinuria. BrJ Rheumatol 1998 37 217-221. 

It has been shown that subjects with renal diseases such as IgA nephropathy, membranous prohferative glomerulonephritis, focal sclerosis, and lupus nephritis have levels of endothelin that are significantly higher than those in healthy subjects [209]. Increased circulating ET-1 concentrations and urinary excretion of ET-1 have been observed in patients treated with the nephrotoxic immunosuppressive agents cyclosporine A and tacrolimus (FK-506) [210]. Other nephrotoxic agents, such as cisplatin, also increase urinary excretion of ET [211]. In patients with chronic renal disease, urinary excretion of ET-1 is significantly elevated when compared to normal values (Table 10). 

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