Cycloserine dosage

Renal function impairment Patients will accumulate cycloserine and may develop toxicity if the dosage regimen is not modified. Patients with severe impairment should not receive the drug. 

D-Cycloserine is a central partial agonist of NMDA receptors in place of P-glycine, which in low doses has shown an antagonism of cognitive deterioration induced by scopolamine. Confusion, disorientation, and memory loss have been observed at high doses. D-Cycloserine can provide a symptomatic treatment of AD at low dosage (Bowen et al. 1992 B. L. Schwartz et al. 1996). 

Cycloserine causes serious dose-related central nervous system toxicity with headaches, tremors, acute psychosis, and convulsions. If oral dosages are maintained below 0.75 g/d, such effects can usually be avoided. 

Cycloserine is an inhibitor of cell wall synthesis and is discussed in Chapter 43. Concentrations of 15-20 mcg/mL inhibit many strains of M tuberculosis. The dosage of cycloserine in tuberculosis is 0.5-1 g/d in two divided doses. Cycloserine is cleared renally, and the dose should be reduced by half if creatinine clearance is less than 50 mL/min. 

Cycloserine. Cycloserine is only used to treat MDR-TB. It is well absorbed orally and is best taken on an empty stomach. It is cleared primarily through the kidneys by glomerular filtration and requires dosage reduction in renal failure. Cycloserine can produce... 

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