Cyclopropyl phenylthio cuprate

Analysis of Reagent Purity an assay to determine relative thermal stabilities can be used to estimate reagent quality and concentration a sample of known volume and temperature Is quenched with excess PhCOCl, and the yield of cyclopropyl phenyl ketone Is measured by GC, the response of which Is calibrated using authentic product and / dodecane as Internal standard. 

Preparative Methods cyclopropylllthlum Is prepared by cooling a 0.25 M THF solution of bromocyclopropane under Ar to —78°C dropwlse addition of 1.0 equiv of a solution of sec-butylllthlum Is followed by stirring for 2 h this cyclopropyl-llthlum solution Is transferred by cannula to a stirred, — 78 °C THF slurry of phenylthIocopper(I) under Ar the resultant mixture Is warmed to —20°C a clear, light brown solution of cuprate forms after stirring for 20 min it is cooled to —78°C and Is used directly.  

A list of General Abbreviations appears on the front Endpapers 

Related Reagents. For related heterocuprates, see lithium methyl (phenylthio) cuprate for discussion of lithium dialkylcup-rates, see lithium dimethylcuprate. 

Alternative preparations include Br-Li exchange in ether using f-BuLi and direct lithiation (a) Seyferth.D. Cohen, H.M.,T Organomet. Chem. 1963, 7,15. (b) Gilman, H. Cartledge, F. K., J. Organomet. Chem. 1964, 

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LITHIUM 1-METHYL-2-(2-METHYL-1-( )-PROPENYL)CYCLOPROPYL(PHENYLTHIO)CUPRATE... 

Lithium 1 -Methyl- 2 - (2 -methyl-1 - ( -propenyl) cyclopropyl (phenylthio) -cuprate... 

Lithium l-Methyl-2-(2-methyl 1 propenyl)cyclopropyl(phenylthio)cuprate 330 University of Bristol, Bristol UK... 

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