Cyclopropanation of methylenecycloalkanes

The introduction of carbenes and carbenoids into synthetic organic chemistry revolutionized the synthesis of cyclopropane derivatives21. In particular, cyclopropanation of methylenecycloalkanes became a very useful method for the preparation of SPC. Moreover, since cycloaddition of carbenes to olefins involves a very fast concerted process (i.e. it eliminates any intermediates during the formation of the three-membered ring)21, the method is equally efficient for the preparation of both unstrained and highly strained compounds. 

Rhodium acetate catalyzed cyclopropanation of methylenecycloalkanes with diazocarbonyl compounds (equation 9) provides a direct method for preparation of functionalized SPC27. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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