Cyclopropa cinnolines

Cyclopent-2-en-l-one, 2-hydroxy-3-methyl-synthesis, 3, 693 Cyclopentenone, 4-methoxy-formation, 1, 423 Cyclopenthiazide as diuretic, 1, 174 Cyclopent[2,3-d]isoxazol-4-one structure, 6, 975 Cydophane conformation, 2, 115 photoelectron spectroscopy, 2, 140 [2,2]Cydophane conformation, 2, 115 Cyclophanes nomenclature, 1, 27 Cyclophosphamide as pharmaceutical, 1, 157 reviews, 1, 496 Cydopiloselloidin synthesis, 3, 743 Cydopolymerization heterocycle-forming, 1, 292-293 6 ff-Cy clopropa[5 a,6a]pyrazolo[ 1,5- a]pyrimidine pyrazoles from, S, 285 Cy dopropab enzopy ran synthesis, 3, 700 Cydopropachromenes synthesis, 3, 671 Cyclopropa[c]cinnolines synthesis, 7, 597 Cyclopropanation by carbenes... 

Cyclopropanation of steroids (363) at the 1,2-position with malonate in the presence of potassium t-butoxide and tetramethylguanidine takes place with formation of the di(alkoxycarbonyl)cyclopropane derivatives (364) accompanied by steroidal cyano-alkoxycarbonylcyclopropanes (365). When the reaction is carried without tetramethylguanidine only minor amounts of cyclopropyl steroids are isolated The formation of the cyano compound is explained by an initial nucleophilic displacement of bromine by the tetramethylguanidine moiety, followed by several steps (equation 119). Although the reaction of equation 120 cannot be classified as a MIRC reaction sensu strictu the formation of cyclopropa[c]cinnolines (367) via an intramolecular 1,1-cycloaddition of nitrilimines is mentioned here. Treatment of o-vinylphenyl-substituted chloroglyoxylate... 

In analogy with the carbenoid 1,1-cyloadditions of nitrile ylides (Section II,B), nitrilimines can undergo intramolecular cyclizations to give 1,2-diazepines or cyclopropa[c]cinnolines (Eq. 41).197 The latter compounds are formed stereospecifically, thus supporting a concerted carbene-like 1,1-addition of the nitrilimine to the olefinic double bond.197a... 

Ethyl l,l-dimethyl-7b-phenyl-la,7b-dihydro-[l//]-cyclopropa[c]cinnoline-lc-carboxylate (192) underwent rearrangement into ethyl 4-isopropenyl-4-phenyl-1,4-dihydro-3-cinnolinecarboxylate (193) (AcOH, reflux, 30 min ... 

Diethyl 1 -phenyl-1 a,7b-dihydro- [ 1 H -cyclopropa [c] cinnoline-1,1 a-dic arboxylate (194) gave a separable mixture of ethyl 4-(a-ethoxycarbonylbenzyl)-l,4-dihydro-3-cinnolinecarboxylate (195) and ethyl 3-cinnolinecarboxylate (196) (AcOH, reflux, 30 min 40% and 5%, respectively, after separation from... 

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