Etanercept Cyclophosphamide

Autoreactive tissue disorders (autoimmune diseases)2 Prednisone, cyclophosphamide, methotrexate, interferon-a and -3, azathioprine, cyclosporine, infliximab, etanercept, adalimumab Often good, variable... 

A 45-year-old woman with resistant rheumatoid arthritis was given etanercept 25 mg twice weekly. Nine days later she developed total acute sensory loss, with flaccid paraplegia, fecal incontinence, and urinary retention. MRI imaging and cerebrospinal fluid analysis were consistent with a diagnosis of transverse myelitis. She also had positive antinuclear and anticardiohpin antibodies. After etanercept withdrawal and treatment with dexa-methasone and cyclophosphamide, her motor function improved with no change in sensory function. 

Doxorubicin, epirubicin, and other anthracyclines, mitoxantrone, cyclophosphamide, 5-fluorouracil, capecitabine, gleevec, sunitinib Trastuzumab, interferon-a-2, interleukin-2, infliximab, etanercept... 

The US manufacturers say that etanercept is not recommended in patients receiving cyclophosphamide. They state that in a study in patients with Wegener s granulomatosis, the addition of etanercept to standard treatment, including cyclophosphamide, was associated with a higher incidence of non-cutaneous solid malignancies. ... 

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