Cyclopeptide cytotoxic activity

Cyclopeptides and depsipeptides having cytotoxic activity, total syntheses of 87YGK957 88YZ1115. 

Cherimolacyclopeptides, cyclic peptides isolated from the methanol extract of the seeds of Annona cherimola. The cherimolacyclopeptides A, B, C, D, E, and E have been isolated and structurally elucidated. In addition, glaucacydopeptides A and B have been discovered in the seeds of Annona glauca. The cyclopeptides were described as having cytotoxic activity in... 

DiazonamidM. The halogenated cyclopeptides D. A and B with unusual CC bridges are isolated from the tunicate Diazona chinensis they have strong in vitro cytotoxic activities against the colon tumor HCT-16... 

Cyclomarin A 98 exhibits cytotoxicity towards cancer cells and has antiinflammatory activity. It is a cyclopeptide isolated from an actinomycete and has attracted the attention of synthetic chemists due to the number of non-natural amino acids present in this structure. The (2S,4R)-D-hydroxyleucine 103 contained within the target has been prepared by using the Davis chiral auxiliary vide supra) Condensation of an enantiopure /7-toluenesulfinamide 100 with aldehyde 99 afforded sulfinimine 101. 

---