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Cyclooxygenases membrane-binding domain

The cyclooxygenase active site lies at the end of a long, narrow, hydrophobic tunnel or channel. Three of the u-helices of the membrane-binding domain lie at the entrance to this tunnel. The... [Pg.834]

FIGURE 1 Structures of COX-1 and COX-2, (a) COX-1 with an NSAID inhibitor (flurbiprofen, orange) bound (PDB ID 3PGH). The enzyme consists of two identical monomers (gray and blue) each with three domains a membrane anchor consisting of four amphipathic helices a second domain that somewhat resembles a domain of the epidermal growth factor and the catalytic domain, which contains the cyclooxygenase and peroxidase activities, as well as the hydrophobic channel in which the substrate (arachidonate) binds. The heme that is part of the peroxidase active sites is shown in red ... [Pg.803]

See other pages where Cyclooxygenases membrane-binding domain is mentioned: [Pg.12]    [Pg.1948]    [Pg.300]    [Pg.231]    [Pg.91]    [Pg.1947]    [Pg.34]    [Pg.87]    [Pg.834]    [Pg.13]    [Pg.6]   
See also in sourсe #XX -- [ Pg.31 ]



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Cyclooxygenase

Membrane binding domain

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