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Cyclooxygenase-2 inhibitors selectivity

The lability of benzylic positions to cytochrome P450 metabolism has been exploited to decrease the unacceptably low clearance and resultant long half-life of various compounds. For example celecoxib, a selective cyclooxygenase inhibitor, has a half-life of 3.5 h in the rat. Early structural leads, represented by compoimds in... [Pg.83]

Spiegel BMR, Targownik L, Dulai GS, Gralnek IM. The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis. Ann Intern Med 2003 138 795-806. [Pg.444]

Knijff-Dutmer EA et al Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclooxygenase-2-selective inhibitors in patients with rheumatoid arthritis. Rheumatology (Oxford) 2002 41 458. [PMID 11961179]... [Pg.821]

Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors Celecoxib (Celebrex ) and Rofecoxib (Vioxx )... [Pg.11]

Kassahun, K., McIntosh, I. S., Shou, M., Walsh, D. J., Rodeheffer, C., Slaughter, D. E., Geer, L. A., Flalpin, R. A., Agrawal, N., Rodrigues, A. D. Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor, Drug Metab. Dispos. [Pg.119]

Komhoff, M., Wang, J. L., Cheng, FI. F., Langenbach, R., McKanna, J. A., Flarris, R. C., Breyer, M. D. Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development, Kidney Int. 2000, 57, 414-422. [Pg.119]

Heise G, Grabensee B, Schror K, Heering P (1998) Different actions of the cyclooxygenase 2 selective inhibitor flo-sulide in rats with passive Heymann nephritis. Nephron... [Pg.130]

Chan et al. (1995), Riendeau et al. (1997) used a fecal 51 Cr excretion assay in rats and primates to detect gastrointestinal integrity after application of a selective cyclooxygenase inhibitor. [Pg.236]

Figure 12.9. Structures of selected cyclooxygenase inhibitors. Rofeeoxib is selective for Cox-2 the selectivity of acetaminophen in vivo is not entirely clear yet. The residual inhibitors act on both Cox-1 and Cox-2. Figure 12.9. Structures of selected cyclooxygenase inhibitors. Rofeeoxib is selective for Cox-2 the selectivity of acetaminophen in vivo is not entirely clear yet. The residual inhibitors act on both Cox-1 and Cox-2.
Breyer MD, Hao C, Qi Z, Breyer MD, Hao C, Qi Z. Cyclooxygenase-2 selective Inhibitors and the kidney. Current Opinion in Critical Care 2001 7 393-400. [Pg.449]

Spilding WM, Reeves MJ, Whelton A. Thromboembolic Cardiovascular Risk Among Arthritis Patients Using Cyclooxygenase-2-Selective Inhibitor or Nonselective Cyclooxygenase Inhibitor Nonsteroidal Anti-inflammatory Drugs. American Journal of... [Pg.456]

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See also in sourсe #XX -- [ Pg.120 , Pg.121 , Pg.122 , Pg.123 , Pg.127 , Pg.128 ]



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Cyclooxygenase

Cyclooxygenase 1/2 inhibitors Cyclooxygenases

Cyclooxygenase inhibitors

Cyclooxygenase-2 Selective Inhibitors

Cyclooxygenase-2 selective

Inhibitors selection

Nonsteroidal anti-inflammatory drugs selective cyclooxygenase-2 inhibitors

Selective Inhibitors of Cyclooxygenase-2 (COX

Selective inhibitor

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