Cyclooxygenase-2 inhibitors pharmacokinetics

Diclofenac is a phenylacetic acid derivative that is relatively nonselective as a cyclooxygenase inhibitor. Pharmacokinetic and dosage characteristics are set forth in Table 36-1. 

Rodrigues AD. Impact of CYP2C9 genotype on pharmacokinetics are all cyclooxygenase inhibitors the same Drug Metab Dispos 2005 33 1567-575. 

One substrate of recent interest is celocoxib, a cyclooxygenase-2 inhibitor (Celebrex ). P450 2C9 is the major catalyst of oxidation, and variants affect the in vivo pharmacokinetic parameters [733, 734]. 

Buvanendran A, Kroin JS, Tuman KJ, et al. Cerebrospinal fluid and plasma pharmacokinetics of the cyclooxygenase 2 inhibitor rofecoxib in humans single and multiple oral drug administration. Anesth Analg 2005 100(5) 1320-1324, table of contents. 

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